Showing posts with label generic drugs. Show all posts
Showing posts with label generic drugs. Show all posts

Tuesday, July 27, 2010

The Guilty Doctor


Times are tight and we're all looking to save money, be it our own or someone else's. Many will say that when it comes to the skyrocketing costs of health care, doctors are responsible for part of the problem. We order too many tests, either to cover ourselves in the event of a malpractice suit, or because patients pressure us, or because we genuinely believe that the tests are necessary for patient care, but in many circumstances, a cheaper option is available. We order medications that are expensive when cheaper medications are available. And psychiatrists offer care-- like psychotherapy-- that could be done by clinicians who are cheaper to educate and willing to work for less money.

Here are some voices on decreasing cost: From KevinMD's post on when patients (in this case the patient is a doctor), pay cash. More on the same story directly from Jay Parkinson, here is Today I Was a Patient. The most absolutely cool thing I learned from Dr. Parkinson this morning is about a website I had never heard of before called
ZocDoc which lets people schedule on-line appointments with new physicians (including shrinks!)--like OpenTable for Docs...I asked for more info about this, but such a website fits Roy's vision of dying and going straight to heaven. And MovieDoc has strong opinions on allocating resources: we shrinks should not be letting patients ramble on about their romantic lives, why one psychiatrist can treat 1,000 patients if they stop that psychotherapy nonsense! ClinkShrink, too, has had a lot to say about allocation of services, but I'll stop now before the blog explodes.

I buy it, too. Docs should feel an obligation to care about cost-containment. In recent times, this translates very simply into the fact that I feel guilty no matter what I do. I sit with a patient and I consider trying a cheaper option for medications before I try a more expensive
one. But then I think: isn't my obligation to do my very best by this patient? Why shouldn't my patients get the latest-greatest available medication when other patients do? And what's the cut-off for how much it's worth for....relief from voices, a better mood, a good night's sleep? How do we even begin to put dollar signs on such things?

I'll give you a scenario. A patient comes to me already on an
anti-psychotic medication. He says it helps, but it's unclear why it was ever started. At some point, he stops taking it, and it becomes much more clear why he ever needed it: he becomes flagrantly psychotic and completely unable to function. I restart the medication, using the one he was on, which happens to be fairly cheap as the second generation anti-psychotics go. So all good: the med works, I know he tolerates it, and it's the cheapest of the choices, by a lot. Oh, until he gains 20 pounds. Now what? There's Abilify which is, oh, many times more expensive, but is less associated with weight gain...should I try that? I hesitate because of the cost, and then I think perhaps I should try one of the older medicines, of the Haldol generation-- much, much cheaper, but many patients hate it. As a field, we seem to agree that these first-generation anti-psychotics are not the way to start; the atypicals are the usual first-line treatment. Maybe this patient won't have side effects, maybe he'll be fine, I could "try." But isn't that making my patient into a guinea pig? If it were me, would I want to try a medication with many known side effects, when other medications are available? Nope. So I go back and forth between what is best for my patient and what makes sense for society. I share some of my thoughts with the patient, whose private health insurance pays for them, and he clearly wants what's best for him, not what saves society money.

I suppose the question presumes that I know what's best for him. And clearly, I don't. One of my big concerns is that he had this awful recurrence of a terrible illness, and each time, it takes weeks to get better,time lost from his life. There is no guarantee that
Abilify, with a more favorable side effect profile, will be equally efficacious, or that Haldol, cheaper if you will, will also work. There is the risk of relapse with any medication change and this is why some patients tolerate medications that cause weight gain or diabetes.

And then there is the "at what cost?" for that particular symptom. A patient wants a medication for sleep--
trazodone and benedryl don't work, ClinkShrink flips when anyone prescribes Seroquel for sleep ($3/pill for 25 mg per drugstore.com), benzodiezepines are contraindicated, and then there's Rozerem at $5/pill. Is a good night's sleep worth $5 night? Of whose money? And what if the patient is on generic Ambien ($1/pill or less) but wants to take Ambien CR ($4/pill) because it helps him sleep longer? And how do you feel about Provigil, which comes in at $20 a pill for the 200mg dose? Stepwise therapy, you say--- where a patient must try cheaper medications before he is allowed access to the more expensive ones? And who determines efficacy? And how do we deal with the hassles of pre-authorization? Maybe we should decide that certain medicines are so expensive that they shouldn't be offered to anyone?

Friday, December 18, 2009

Do Generics Work as Well as Name Brands?


It's my first night of vacation! I saw my last patient today and then started pulling the pictures off the walls in anticipation of my move. I ran over to see the new place, and it still needs insulation (it's on the floor), paint, and carpet. And doorknobs might be nice.

So we're expecting quite the snowstorm here. I'll let you know how it goes tomorrow, but the current forecast is for up to 20 inches. It didn't take me long to float from the weather to the health section of the New York Times, and here's an article by Leslie Alderman about generics versus name brands.

Are generics as good as name brands? I don't have any studies, I'm purely running on anecdotes, but this is my thinking: Usually. When I was resident, I learned that 15% of the time (and this isn't science, I don't think, I believe it's someone else's anecdote) generic nortryptiline doesn't work when name brand Pamelor does. So I've always asked patients to start with Pamelor....I don't use it much anymore....because who wants to spend 6-8 weeks on a medication trial and have someone not respond only to realize they were in that small group of patients who are sensitive to the brand.

Other meds: I've had a handful of people complain about generic Prozac-- fluoxetine. It's not as effective for them, or they have more side effects. Alderman's article talks about Wellbutrin XL and I didn't even realize that the XL form now has a generic. Sometimes people want the name brand.

So what do I do when a patient specifically requests the name brand? I give it to them: if they are right, then they are right. And if they simply believe that they won't respond to the generic, because there are people who say "Generics don't work on me," well, then there's power to such beliefs, and I just want my patients to get better.

What do you think?

Friday, January 18, 2008

Fluoxoperidonacaine: How drugs get their name



Ladyk73 (aka LadyAK47) asked a while back about how drugs get their names.
Hello there! I have a question!!!!!!
(I can imagine Roy crawling into the dungeons of some long-lost medical library somewhere to find the answer to this)

Anyways, this is really bothering me.

When I was a C-/D+ pharmacy student, one of the few things I learned was that there was some sort of nomenclature that was used to name drugs. The generic/chemical name, not those fancy drug pushers name....

Why does Trazodone have an -one suffix? As in a whole lot of corticosteriods end in -one.
What does the -one in trazadone stand for? Or does any of the name can be explained by nomenclature ways?
Great question!  Glad you asked...

The drug names are all decided by Tony, Bill, David, Peter, and Darin.

These are the most recent members of the USAN, the United States Adopted Name Council.  This is a 5-member organization consisting of representatives from the AMA, APhA, USP, FDA, and a member-at-large.  USAN works with the World Health Organization to come up with rules for naming drugs, and agrees on new drug names after the manufacturer applies for a new name (usually after submitting the drug to the FDA as an IND (Investigational New Drug).

There is a list of rules for naming drugs, typically based on their chemical structure, their therapeutic indication, or their mechanism of action.  Examples:

a.  The name for the active moiety of a drug should be a single word, preferably with no more than four syllables.
b.  The name for the active moiety may be modified by a single term, preferably with no more than four syllables, to show a chemical modification, such as salt or ester formation.  Examples can include cortisone acetate from cortisone, cefamandole sodium from cefamandole or erythromycin acistrate from erythromycin.
c.  Only under compelling circumstances is a name with more than one modifying term acceptable.  Compelling circumstances may pertain to such examples as pharmaceuticals containing radioactive isotopes or the different classes of interferons.
d.  Acronyms, initials and condensed words may be acceptable in otherwise appropriate terminology.


To see the entire list of rules, go to this .pdf, the USAN Stem List.  Examples:

CHEMICAL SUFFIX TYPE OF MEDICATION EXAMPLES
-anserin

serotonin 5-HT2 receptor antagonists altanserin, tropanserin, adatanserin 
-azepamantianxiety agents (diazepam type) lorazepam 

-peridol antipsychotics (haloperidol type) haloperidol 
-peridone antipsychotics (risperidone type) risperidone, iloperidone 
-perone antianxiety agents/neuroleptics duoperone  
-pezil acetylcholinesterase inhibitors used in the treatment of Alzheimer’s disease donepezil , icopezil
-pidem hypnotics/sedatives (zolpidem type) zolpidem alpidem 
-pirdine cognition enhancers linopirdine, besipirdine, sibopirdine

Wednesday, October 10, 2007

Generic Trileptal (Oxcarbazepine) Approved

The FDA just approved a generic Trileptal, an anticonvulsant related to the mood stabilizer, Tegretol (carbamazepine), and sometimes used to treat bipolar disorder. It is thought to have fewer problems with liver toxicity than Tegretol.

See the FDA announcement for more details. Three companies were approved to make the new generic.